[DOWNLOAD] ~ Is Surgical Excision Necessary for the Management of Atypical Lobular Hyperplasia and Lobular Carcinoma in Situ Diagnosed on Core Needle Biopsy? A Report of 38 Cases and Review of the Literature (Report) by Archives of Pathology & Laboratory Medicine ~ Book PDF Kindle ePub Free
eBook details
- Title: Is Surgical Excision Necessary for the Management of Atypical Lobular Hyperplasia and Lobular Carcinoma in Situ Diagnosed on Core Needle Biopsy? A Report of 38 Cases and Review of the Literature (Report)
- Author : Archives of Pathology & Laboratory Medicine
- Release Date : January 01, 2008
- Genre: Health & Fitness,Books,Health, Mind & Body,
- Pages : * pages
- Size : 268 KB
Description
Lobular carcinoma in situ (LCIS) and atypical lobular hyperplasia (ALH) are high-risk breast lesions traditionally associated with an increased risk of malignancy in either breast. As compared to the risk in the general population, the risk of development of breast cancer is increased 4 to 5 times after a diagnosis of ALH and approximately 11 times after a diagnosis of LCIS. (1-3) Analysis of Surveillance, Epidemiology and End Results data shows the minimum risk of developing invasive breast cancer after a diagnosis of LCIS to be approximately 7.1% at 10 years with equal predisposition for either breast. (4) The traditional view of LCIS as a risk factor for the development of subsequent invasive carcinoma has been recently challenged. Current evidence utilizing molecular and genetic techniques suggests that LCIS and ALH may be indolent precursors of carcinoma rather than just markers of risk. (5,6) This finding would lead to changes in the current management recommendations for patients diagnosed with ALH or LCIS, leading to altered treatment decisions. Currently, while most cases of LCIS diagnosed at surgical excision are managed conservatively with mammographic and clinical follow-up, the management guidelines for treatment of ALH or LCIS diagnosed by percutaneous core biopsy (PCB) has remained controversial. This is due to the small number of reports described in the literature that focus on the surgical follow-up of cases diagnosed as either ALH or LCIS on PCB. (7-32) Also noted is the rarity of ALH or LCIS on PCB, with most series reporting incidences of less than 2%. (7-8,11-12,16,18,28) We reviewed our experience with pure LCIS or ALH diagnosed by PCB and correlated these cases with radiologic findings and surgical excision diagnoses to develop management guidelines for lobular neoplasia diagnosed by PCB. MATERIALS AND METHODS
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